Key Takeaway: Thyroid hormones stimulate mitochondrial uncoupling protein (UCP-1/3) activity. Unmanaged hypothyroidism lowers BMR by 10–25%. Once hormone replacement is clinically titrated, energy balance thermodynamics function normally.
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Scientific References & Clinical Studies
- Thyroid hormone regulation of metabolism — Physiol Rev. Mullur R et al.
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Referências e Estudos Científicos
- Self-monitoring in weight loss: a systematic review — J Am Diet Assoc.
- Dietary energy density and behavioral compliance — Lancet Diabetes Endocrinol.